I suffer with my hands, particularly in the Winter when my hands stay wetter for longer.
I've tried various barrier creams, including Derma Shield (Google for it) which costs around £30 a can, but in the end I have had to wear gloves.
I've tried Unger gloves, but they didn't seem to last long (a few weeks in some cases before leaking), they also made my hands stink and at £20 - £25 a pair they weren't cheap for a pair of 'disposable' gloves.
Then I switched to a cotton inner and a rubber gloved outer (not a pink marigold mind). When the inner gets wet from sweat - I just switch to a dry pair. They take a little getting used to - a little bit bulky for writing out an invoice - but they do protect your hands 100%.
I also use a quality hand cream, such as Nuetrogena (spelling?) and have a hydrocortisone cream for when my ezema breaks out.
Fairy also really dries out my hands, so sometimes I'll switch to a 'professional' window cleaning fluid. Not because it cleans the windows better, but just to give my hands a break.
It's a pain being so sensitive!