If you use double DI you are wasting resin if you use anything but 000. I change mine at 001.
Think about it. If the SECOND bottle is going up, the first bottle has long since had it. You will be throwing away spent resin either way, but once you move the bottle 2 back to position 1, wouldn't it be better if it was at least doing some purifying?
The longer you leave it, the less effective double DI is.