I used to drive an escort 55 with a 250 litre upright tank and it was like being the captain of a ship in a squall, when it was full. It was slow and the drive experience was like the van was top heavy.
I now have a 400l tank in the back of a 1.9 dispatch and my van feels alot more stable.
As for best i don't know.
I would consider getting an upright tank in the future to create more space, but i think i would probably end up playing safe and get a lay flat tank because the drive feels steadier than when i had the upright.
If i had a bigger van i could be swayed by positive experiences of people driving similar vans with and upright tank.