They have told me it works, I think I've actually tried it aswell with no problem, can't remember, but Palm doesn't have drivers for Vista (atleast not for my Palm Zire 31), 32bit Vista works with the XP drivers with limited functionality , but 64bit is problematic, no hotsyncing at all.
If George doesn't work 100% allright you can always try running it in 2000/XP compatibility mode.