That's interesting thanks for your replies.
I've set mine up after pre-filters and seems to be working ok.
Although I might play around and try it before pre-filters to see if it makes any difference.
Im happy with the performance of the 4040 with the booster pump (Clarke cbm240e) as production is much much faster than my old 400 gpd ro.
The only slight problem I was having when setting up was that if I closed the waste valve too much it blew the inlet hozelock connector off of the pre-filter.
I presume this was due to too much back pressure?