No it has nothing to do with the tds.
You restrict the waste to build more preasure in the r/o, It was recomended to me to set it up 50 x 50, if you set it up so you get 40% waste and 60% pure the r/o membrane will not flush as well and sludge up.
I have a tds reading of 234tds at the tap and that comes down to 0.01 after the r/o, then the water is stored in the holding tank, and it is not polished with resin untill the last minute.
How I flush mine is very simple, I have a tap on the pure water out pipe from the r/o. you close this tap and open the flow control on the waste and hence the water flushes across the membraine at mains presure and down the waste.
A tip is mark the position of the flow control on the waste then when you have flushed the r/o, return the flow control on the wast to the same position as before and open the tap on the pure water side.
Roy